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Publications of Dr. Yue Liu (CEO & Founder)


Patent Publications


1. Compositions and methods for treating diseases of protein aggregation involving ic3b deposition

United States Patent Application US 20140127225 A1

Inventors: Guriqbal S. Basi, Robin Barbour, Yue Liu


2. Tau immunotherapy


United States Patent Application WO 2014165271 A2

Inventors: Peter Seubert, Philip James DOLAN III, Yue Liu, Robin Barbour


3. Antibodies that recognize IAPP


United States Patent Application WO2015004632

Inventors: BARBOUR, Robin, Yue Liu


4. Anti-mcam antibodies and associated methods of use


United States Patent Application WO 2015136470 A1

Inventors: Yue Liu, Patrick Garidel, Andreas Langer


5. Anti-mcam antibodies and associated methods of use


United States Patent Application WO 2015136469 A1

Inventors: Yue Liu


6. Anti-laminin4 antibodies specific for lg4-5


United States Patent Application WO 2015136472 A1

Inventors: Stephen Jed TAM, Yue Liu, Robin Barbour, Theodore Yednock


7. Anti-laminin4 antibodies specific for lg1-3


United States Patent Application WO 2015136471 A1

Inventors: Kenneth Flanagan, Stephen Jed TAM, Yue Liu, Theodore Yednock, Robin Barbour


8. Combination treatment for multiple sclerosis


United States Patent Application WO 2015136468 A1

Inventors: Stephen Jed TAM, Theodore Yednock, Yue Liu, Nicholas SCHWAB, Heinz Wiendl, Tilman SCHNEIDER-HOHENDORF


9. Anti-transthyretin antibodies


United States Patent Application WO2016120811 A1

Inventors: Yue Liu, Avijit Chakrabartty, Jeffrey N. Higaki


10. Anti-transthyretin antibodies


United States Patent Application WO2016120810 A1

Inventors: Yue Liu, Tarlochan S. Nijjar, Avijit Chakrabartty



Research Publications


1. Su, Yang., Liu, Y*., Behrens, C., Bidlingmaier, S., Lee, N., Aggarwal, R., Sherbenou, D., Burlingame, A., Hann, B., Simko, J., Premasekharan, G., Paris, P., Shuman, M., Seo, Y., Small, E. and Liu, B. 2018. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. J. Clinical Invest. (* co-first author, accepted).


2. Pennella MA, Liu Y*, Woo JL, Kim CA, Berk AJ. 2010. Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies. J. Virol. Dec, 2010. 84(23):12210-25. Epub 2010 Sep 22. (* co-first author).


3. Liu, Y., A. Shevchenko, A. Shevchenko and A. J. Berk. 2005. Adenovirus exploits the cellular aggresome response to inactivate the MRN complex. J. Virol. 79: 14004-16 (spot light section). One figure of this publication has been selected as the cover page image on J. Virol. May, 2006. 80: 9.


4. Zhao, L. Y., Y. Liu*, N. R. Bertos, X. J. Yang and D. Liao. 2003. PCAF is a coactivator for p73-mediated transactivation. Oncogene 22: 8316-29 (* co-first author).


5. Liu, Y., A. Colosimo, X. J. Yang and D. Liao. 2000. Adenovirus E1B 55-Kilodalton oncoprotein inhibits p53 acetylation by PCAF. Mol. Cell. Biol. 20: 5540-53.


6. Liu, Y., L. Xia, J. Fu, C. Ruan, H. Wan and P. Li. 1997. Construction and expression of a functional murine human chimerical antibody against human cross-linked fibrin. Zhonghua Xue Ye Xue Za Zhi (Chinese Journal of Hematology) 18: 449-52.


7. Liu, Y., L. Xia, J. Fu, X. Bai, H. Wang, P. Li and C. Ruan. 1996. Construction and expression of a chimerical Fab fragment of anti-fibrin monoclonal antibody SZ-58 in E.coli. Chinese Journal of Microbiology & Immunology 16: 100-4.


8. Scott Bidlingmaier, Xiaodong Zhu, Yue Liu, Yang Su, Bin Liu. 2013. Novel Internalizing Human Antibodies Targeting Brain Tumor Sphere Cells. Stem Cells and Cancer Stem Cells 9:187-190


9. Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B. 2011. Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics. 10(3)


10. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. 2011. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 32(10):2605-13



Publications of Dr. Jianbo Dong (Director)


1. Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong , Zhengda Sun, Consuelo, Garcia‐Rodriguez, Shauna Farr‐Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier and James D. Marks (2018) A Single Tri‐Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A. Toxins. 10, 84; doi:10.3390/toxins10020084


2. Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren IN, Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. (2015) Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B. Toxins. 7(9):3405-23. Doi:10.3390/toxins7093405


3. Fan Y, Geren IN, Dong J, Lou J, Wen W, Conrad F, et al. (2015) Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. PLoS ONE 10(8): e0135306. doi:10.1371/journal.pone.0135306


4. Dong J*, Thompson A*, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson B, Stevens R, and Marks J. (2010) A Single Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic Alpha-Exosite Binding Region. J Mol Bio. 397(4), 1106-18.


5. Dong J*, Shi N*, Berke I, Chen L, and Jiang Y. (2005) Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability. J Biol Chem. 280, 41716-24.


6. Dong J, Feng Y, and Wandinger-Ness A. (2004) XAPC7, a proteasome Alpha Subunit, Interacts Specifically with Rab7. J Biol Chem. 279, 21334-42.


7. Stein M, Dong J and Wandinger-Ness A. (2003) Rab proteins and endocytic trafficking: potential targets for therapeutic intervention. Advance Drug Dilivery Reviews. 14, 1421-37


8. Dong J, Tang T, and Sun F. (2000) Chicken and Xenopus sperm contain a cytosolic soluble factor which can trigger calcium oscillations in mouse eggs. Biochemical and Biophysical Research Communication. 268, 947-951.


9. Tang T, Dong J, Huang X, and Sun, F. (2000) Ca2+ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs. Development. 127, 1141-1150.